Concepedia

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Hongyu Zhao, Gang Liu, Zhili Xin, Michael D. Serby, Zhonghua Pei, Bruce G. Szczepankiewicz, Philip J. Hajduk, Cele Abad‐Zapatero, Charles W. Hutchins, Thomas Lübben,

Bioorganic & Medicinal Chemistry Letters · 2004 · 81 citations · 20 references

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20

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Lori D. Klaman, Olivier Boss, Odile D. Peroni et al. · Molecular and Cellular Biology · 2000 · 1.2K citations

, , +17

PTP1B Regulates Leptin Signal Transduction In Vivo

Janice M. Zabolotny, Kendra K. Bence, Alain Stricker‐Krongrad et al. · Developmental Cell · 2002 · 820 citations · Full text

, , +9

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

David Barford, Andrew Flint, Nicholas K. Tonks · Science · 1994 · 759 citations

, , +17

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

Barry I. Posner, Robert Faure, J.W. Burgess et al. · Journal of Biological Chemistry · 1994 · 537 citations · Full text

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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan et al. · Proceedings of the National Academy of Sciences · 2002 · 416 citations

, , +17