Charles W. Hutchins

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Bruce G. Szczepankiewicz, Gang Liu, Philip J. Hajduk et al. · Journal of the American Chemical Society · 2003 · 226 citations · Full text

Type Ii Diabetes, Drug Target, Biochemistry +15

Fragment Screening and Assembly:  A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Gang Liu, Zhili Xin, Zhonghua Pei et al. · Journal of Medicinal Chemistry · 2003 · 160 citations · Full text

Drug Target, Protein Assembly, Molecular Biology +17

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Bruce G. Szczepankiewicz, Christi Kosogof, Lissa T.J. Nelson et al. · Journal of Medicinal Chemistry · 2006 · 159 citations · Full text

Little Inhibitory Activity, Drug Target, Pharmacotherapy +21

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Christina K. Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta‐Vellve et al. · Nature · 2023 · 145 citations · Full text

Discovery of <i>N</i>-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Keith F. McDaniel, Le Wang, Todd Soltwedel et al. · Journal of Medicinal Chemistry · 2017 · 133 citations · Full text