Molecular architecture of the chick vestibular hair bundle

Jung Bum Shin, Jocelyn F. Krey, Ahmed M. Hassan, +12

Nature Neuroscience

BiologyPattern FormationVestibular SystemNatural SciencesMolecular Architecture +7

Relay Ring-Closing Metathesis (RRCM):  A Strategy for Directing Metal Movement Throughout Olefin Metathesis Sequences

Thomas R. Hoye, Christopher S. Jeffrey, Manomi A. Tennakoon, +2

Journal of the American Chemical Society

Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation

Hongshi Xu, Hongyu Zhao, Wei Tian, +3

Journal of Biological Chemistry

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

Reo Maeda, Katie S. Kindt, Weike Mo, +6

Proceedings of the National Academy of Sciences

Some Allylic Substituent Effects in Ring-Closing Metathesis Reactions:  Allylic Alcohol Activation

Thomas R. Hoye, Hongyu Zhao

Organic Letters

Allylic SubstituentsCross-coupling ReactionAllylic Alcohol ActivationEngineeringAlkene Metathesis +12

Fragment Screening and Assembly:  A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Gang Liu, Zhili Xin, Zhonghua Pei, +11

Journal of Medicinal Chemistry

Drug TargetProtein AssemblyMolecular BiologyReceptor Tyrosine KinaseProtein X-ray Crystallography +15

TOP2A Promotes Tumorigenesis of High-grade Serous Ovarian Cancer by Regulating the TGF-β/Smad Pathway

Yan Gao, Hongyu Zhao, Meng Ren, +5

Journal of Cancer

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Hongyu Zhao, Gang Liu, Zhili Xin, +13

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineReceptor Tyrosine KinaseMechanism Of ActionIsoxazole Carboxylic Acids +5

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

Zhili Xin, Hongyu Zhao, Michael D. Serby, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineRational Drug DesignPharmacotherapyDrug Development +3

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH₂-Terminal Kinase Inhibitors

Hongyu Zhao, Michael D. Serby, Zhili Xin, +17

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyChemical BiologyInsulin SignalingPharmaceutical Chemistry +17