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Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

Kirsty R. Greenow, Alan R. Clarke, Robert H. Jones

Oncogene · 2009 · 41 citations · 24 references

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References

24

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.4K citations · Full text

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan · Nature · 2003 · 3.4K citations

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Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

, , +17

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

Jos Jonkers, Ralph Meuwissen, Hanneke van der Gulden et al. · Nature Genetics · 2001 · 1.1K citations

, , +16

Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139

Emmy P. Rogakou, Wilberto Nieves‐Neira, Chye Boon et al. · Journal of Biological Chemistry · 2000 · 714 citations · Full text

, , +17