Cell · 2014 · 346 citations · 56 references
Life SciencesEndocrinologyPhysiologyNeuroendocrinologyPathophysiologySignal TransductionHypothalamic-pituitary RegulationReceptor RegulationBlood PressureDorsomedial NucleusLep MutationsLepr MutationsLeptin SignalingLoss-of-function MutationsLoss-of-function Receptor MutationsObesity Physiology
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Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Carl Montague, I. Sadaf Farooqi, Jonathan P. Whitehead et al. · Nature · 1997 · 2.9K citations · Full text
Medicine, Endocrinology, Pediatrics +11
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Michael A. Cowley, James L. Smart, Marcelo Rubinstein et al. · Nature · 2001 · 2.3K citations · Full text