Activation of CYP2C9-Mediated Metabolism by a Series of Dapsone Analogs: Kinetics and Structural Requirements

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

International Journal of Biochemistry · 1994 · 3K citations

Life Sciences, Biochemistry, Chemistry +16

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Allan E. Rettie, Kenneth R. Korzekwa, Kent L. Kunze et al. · Chemical Research in Toxicology · 1992 · 602 citations

Medicine, Pharmacology, Toxicology +17

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 519 citations

Medicine, Pharmacokinetics, Pharmacology +17

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

Magang Shou, James Grogan, Julie Mancewicz et al. · Biochemistry · 1994 · 350 citations

Medicine, Biochemistry, Pharmacology +17

Human Cytochrome P-450 3A4: In Vitro Drug-Drug Interaction Patterns Are Substrate-Dependent

Regina W. Wang, Deborah J. Newton, Nini Liu et al. · Drug Metabolism and Disposition · 2000 · 240 citations

Medicine, Biochemistry, Pharmacology +17