Concepedia

Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity

Yu Wang, Lance S. Davidow, Anthony C. Arvanites, Joel Blanchard, Kelvin Lam, Ke Xu, Vatsal Oza, Jin Woo Yoo, Jessica M.Y. Ng, Tom Curran,

Chemistry & Biology · 2012 · 71 citations · 47 references

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47

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

, , +16

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

, , +13

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rajat Rohatgi, Ljiljana Milenković, Matthew P. Scott · Science · 2007 · 1.5K citations

, , +17

Activating Smoothened mutations in sporadic basal-cell carcinoma

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh et al. · Nature · 1998 · 1.3K citations

, , +10