Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer

A proposal for the classification of sigma binding sites

Rémi Quirion, Wayne D. Bowen, Yossef Itzhak et al. · Trends in Pharmacological Sciences · 1992 · 754 citations

Pharmacy, Molecular Biology, Molecular Recognition +7

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

Bertold J. Vilner, Christy S. John, W D Bowen · PubMed · 1995 · 488 citations

Medicine, Oncology, Pharmacology +10

Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

Susan B. Hellewell, Ashley Bruce, Glen I. Feinstein et al. · European Journal of Pharmacology Molecular Pharmacology · 1994 · 437 citations

Medicine, Biochemistry, Pharmacology +12

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

Susan B. Hellewell, W. Don Bowen · Brain Research · 1990 · 388 citations

Medicine, Neuroscience, Pharmacology +8

Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines.

Keith W. Crawford, Wayne D. Bowen · PubMed · 2002 · 241 citations

Medicine, Oncology, Pharmacology +10