Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer

Amalia Azzariti, Nicola Antonio Colabufo, Francesco Berardi, +5

Molecular Cancer Therapeutics

Breast OncologyLow SigmaChemoprevention StrategyImmunologyPharmacotherapy +17

Antiproliferative and cytotoxic effects of some ?2 agonists and ?1 antagonists in tumour cell lines

NicolaAntonio Colabufo, Francesco Berardi, Marialessandra Contino, +4

Naunyn-Schmiedeberg s Archives of Pharmacology

Cytotoxic EffectsTumour Cell LinesChemoprevention StrategyMedicinePharmacology +8

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryNatural SciencesOrganic ChemistryTetrahydroisoquinoline DerivativesChemistry +2

Structure−Affinity Relationship Study on<i>N</i>-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-Piperazinealkylamides, a New Class of 5-Hydroxytryptamine₇Receptor Agents

Marcello Leopoldo, Francesco Berardi, Nicola Antonio Colabufo, +5

Journal of Medicinal Chemistry

Molecular PharmacologyDrug TargetBiochemistryFunctional SelectivityMedicine +11

Elements in support of the ‘non-identity’ of the PGRMC1 protein with the σ2 receptor

Carmen Abate, Mauro Niso, Vittoria Infantino, +2

European Journal of Pharmacology

Protein FunctionMolecular PhysiologySignal TransductionPgrmc1 ProteinMolecular Regulation +10

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

Giuseppe Cassano, Giuseppe Gasparre, Mauro Niso, +3

Cell Calcium

Signal TransductionSignaling PathwaySynthetic AgonistSk-n-sh CellsSigma-2 Receptor +8

Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity

Mauro Niso, Carmen Abate, Marialessandra Contino, +5

ChemMedChem

Is the σ₂ Receptor a Histone Binding Protein?

Nicola Antonio Colabufo, Francesco Berardi, Carmen Abate, +3

Journal of Medicinal Chemistry

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, +7

Bioorganic & Medicinal Chemistry

Potent P-gp ModulatorsBiochemistryMedicineOrganic ChemistryHeterocycle Chemistry +4

Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers

Carmen Abate, Mauro Niso, Enza Lacivita, +3

Journal of Medicinal Chemistry

Potential UsePharmacotherapyPharmaceutical ChemistryChiral AnaloguesMolecular Pharmacology +18