Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, +303

Science

Viral DiagnosticsCovid-19 PandemicViral PathogenesisImmunologyMolecular Biology +10

Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer

Amalia Azzariti, Nicola Antonio Colabufo, Francesco Berardi, +5

Molecular Cancer Therapeutics

Breast OncologyLow SigmaChemoprevention StrategyImmunologyPharmacotherapy +17

Antiproliferative and cytotoxic effects of some ?2 agonists and ?1 antagonists in tumour cell lines

NicolaAntonio Colabufo, Francesco Berardi, Marialessandra Contino, +4

Naunyn-Schmiedeberg s Archives of Pharmacology

Cytotoxic EffectsTumour Cell LinesChemoprevention StrategyMedicinePharmacology +8

High Affinity and Selectivity on 5-HT1A Receptor of 1-Aryl-4-[(1-tetralin)alkyl]piperazines. 2

Roberto Perrone, Francesco Berardi, Nicola Antonio Colabufo, +6

Journal of Medicinal Chemistry

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryNatural SciencesOrganic ChemistryTetrahydroisoquinoline DerivativesChemistry +2

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

John R. Hornick, Suwanna Vangveravong, Dirk Spitzer, +5

Journal of Experimental & Clinical Cancer Research

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor

Peter B. Hedlund, Marcello Leopoldo, Silvio Caccia, +6

Neuroscience Letters

Functional SelectivityMedicineSerotonin 5-Ht7 ReceptorPsychopharmacologyNeuropeptide Receptor +5

Structure−Affinity Relationship Study on <i>N</i>-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as Potent and Selective Dopamine D₃ Receptor Ligands

Marcello Leopoldo, Francesco Berardi, Nicola Antonio Colabufo, +4

Journal of Medicinal Chemistry

4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cyclohexylpiperazine as σ Receptor Ligands with Agonist σ₂ Activity

Francesco Berardi, Savina Ferorelli, Carmen Abate, +4

Journal of Medicinal Chemistry

Structure−Affinity Relationship Study on<i>N</i>-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-Piperazinealkylamides, a New Class of 5-Hydroxytryptamine₇Receptor Agents

Marcello Leopoldo, Francesco Berardi, Nicola Antonio Colabufo, +5

Journal of Medicinal Chemistry

Molecular PharmacologyDrug TargetBiochemistryFunctional SelectivityMedicine +11