Concepedia

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

Susan B. Hellewell, W. Don Bowen

Brain Research · 1990 · 388 citations · 36 references

Concepts

MedicineNeurosciencePharmacologyCellular NeuroscienceMolecular PharmacologyNeuropharmacologyLigand BindingNeurotransmissionNeurotransmitter ReceptorsReceptor BindingSigma Receptor Signaling

References

36

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

LA Greene, Arthur S. Tischler · Proceedings of the National Academy of Sciences · 1976 · 5.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Erik H.F. Wong, J A Kemp, Tony Priestley et al. · Proceedings of the National Academy of Sciences · 1986 · 1.8K citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

Richard F. Squires · Proceedings of the National Academy of Sciences · 1977 · 1.3K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12