Synthesis of Fused Tetrahydrofuran‐γ‐lactone Motifs via One‐Pot Ring Expansion of Cyclopropane Rings

Abstract

Abstract An efficient method for constructing fused tetrahydrofuran‐γ‐lactone scaffolds, such as 8, is presented. Key to this strategy is an acid‐catalyzed ring expansion of cyclopropyl precursor 6 that proceeds in the presence of MeSO3H in acetone and produces the desired bicyclic system in good to excellent yields.