Concepedia

Blocking effects of genistein on cell proliferation and possible mechanism in human gastric carcinoma

Hongbin Cui

World Journal of Gastroenterology · 2005 · 17 citations · 16 references

DOIFull text

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Abstract

The growth and proliferation of SGC-7901 cells can be inhibited by genistein via blocking the cell cycle, with reduced expression of cyclin D1 and enhanced expression of cyclin B1 and p21(waf/cip1) protein in the concentration range of 0-20 microg/mL.

References

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Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis

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Gene Expression Profiles of Genistein-Treated PC3 Prostate Cancer Cells

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