4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

HDAC6 is a microtubule-associated deacetylase

Charlotte Hubbert, Amaris R. Guardiola, Rong Shao et al. · Nature · 2002 · 2.3K citations

Biochemistry, Natural Sciences, Microtubule-associated Deacetylase +4

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Stephen J. Haggarty, Kathryn M. Koeller, Jason Chun Yu Wong et al. · Proceedings of the National Academy of Sciences · 2003 · 1K citations · Full text

Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

Purva Bali, Michael Pranpat, James E. Bradner et al. · Journal of Biological Chemistry · 2005 · 746 citations · Full text

HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Xiaohong Zhang, Zhigang Yuan, Yingtao Zhang et al. · Molecular Cell · 2007 · 714 citations · Full text

Signal Transduction, Molecular Regulation, Physiology +8

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

Akihisa Matsuyama · The EMBO Journal · 2002 · 695 citations · Full text

Hdac6-mediated Deacetylation, Cytoskeleton, Cell Manipulation +4