Piperidine renin inhibitors: from leads to drug candidates

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

Marc A. Pfeffer, Eugene Braunwald, Lemuel A. Moyé et al. · New England Journal of Medicine · 1992 · 6K citations

Medicine, Cardiology, Pharmacology +13

Angiotensin II-forming pathways in normal and failing human hearts.

H Urata, Bernadine Healy, Robert W. Stewart et al. · Circulation Research · 1990 · 581 citations · Full text

Medicine, Cardiology, Pharmacology +11

NF-κB Inhibition Ameliorates Angiotensin II–Induced Inflammatory Damage in Rats

Dominik N. Müller, Ralf Dechend, Eero Mervaala et al. · Hypertension · 2000 · 401 citations

Medicine, Nephrology, Pharmacology +16

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum et al. · Chemistry & Biology · 2000 · 321 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of a distinct binding site for angiotensin II (3–8), a putative angiotensin IV receptor

Geoffrey N. Swanson, Jodie M. Hanesworth, Michael F. Sardinia et al. · Regulatory Peptides · 1992 · 269 citations

Medicine, Biochemistry, Pharmacology +11