Synthesis of glycosyl-isoindigo derivatives

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Ralph Hoessel, Sophie Leclerc, Jane Endicott et al. · Nature Cell Biology · 1999 · 814 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Sophie Leclerc, Matthieu Garnier, Ralph Hoessel et al. · Journal of Biological Chemistry · 2001 · 723 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3<i>Z</i>)-ylidenemethyl]-2,4- dimethyl-1<i>H</i>-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Li Sun, Chris Liang, Sheri Shirazian et al. · Journal of Medicinal Chemistry · 2003 · 520 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2

Deborah Moshinsky, Cornelia Bellamacina, D.C. Boisvert et al. · Biochemical and Biophysical Research Communications · 2003 · 50 citations

Life Sciences, Biochemistry, Molecular Biology +15

Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives

Samir Messaoudi, Martine Sancelme, Valérie Polard-Housset et al. · European Journal of Medicinal Chemistry · 2004 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13