A GM-CSF/CD40L Producing Cell Augments Anti-tumor T Cell Responses

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Marina Cella, Doris Scheidegger, Kathrin Palmer-Lehmann et al. · The Journal of Experimental Medicine · 1996 · 2K citations · Full text

Cd40-cd40l Interaction, T-regulatory Cell, Immunology +18

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

Dmitry I. Gabrilovich, Hailei L. Chen, Khaled R. Girgis et al. · Nature Medicine · 1996 · 2K citations

Endothelial Cell Pathobiology, Human Tumors, Angiogenesis +12

Activation of human dendritic cells through CD40 cross-linking.

Christophe Caux, Catherine Massacrier, Béatrice Vanbervliet et al. · The Journal of Experimental Medicine · 1994 · 1.3K citations · Full text

Inflammation, Autoimmune Disease, T-regulatory Cell +15

Induction of tolerance by IL-10-treated dendritic cells

Kerstin Steinbrink, Matthias Wölfl, Helmut Jonuleit et al. · The Journal of Immunology · 1997 · 1.2K citations · Full text

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Franz Koch, Ursula Stanzl, Patricia Jennewein et al. · The Journal of Experimental Medicine · 1996 · 928 citations · Full text

Il-12 Induction, Immunology, Immunologic Mechanism +16