Design and synthesis of C-8 linked pyrrolobenzodiazepine–naphthalimide hybrids as anti-tumour agents

Design of Sequence-Specific DNA-Binding Molecules

Peter B. Dervan · Science · 1986 · 839 citations

Life Sciences, Biomolecular Engineering, Molecular Biology +16

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

D. Subhas Bose, Andrew S. Thompson, Jingshan Ching et al. · Journal of the American Chemical Society · 1992 · 136 citations

Pharmacy, Medicinal Chemistry, Bioorthogonal Chemistry +8

Proposed structure of the anthramycin–DNA adduct

Laurence H. Hurley, R. Petrusek · Nature · 1979 · 121 citations

Life Sciences, Biochemistry, Molecular Biology +11

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents

David E. Thurston, D. Subhas Bose, Andrew S. Thompson et al. · The Journal of Organic Chemistry · 1996 · 114 citations

Pharmacy, Chemistry, Medicinal Chemistry +11