Stephen J. Gregson

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon et al. · Bioconjugate Chemistry · 2013 · 246 citations

Pharmacy, Oncology, Pharmacology +17

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

John A. Hartley, Victoria J. Spanswick, Natalie Brooks et al. · Cancer Research · 2004 · 137 citations

Medicine, Oncology, Pharmacology +15

Linker Length Modulates DNA Cross-Linking Reactivity and Cytotoxic Potency of C8/C8‘ Ether-Linked C2-<i>exo</i>-Unsaturated Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine (PBD) Dimers

Stephen J. Gregson, Philip W. Howard, Darren R. Gullick et al. · Journal of Medicinal Chemistry · 2004 · 92 citations

Medicine, Medicinal Chemistry, Pharmacology +10

SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads

Krista Kinneer, John Meekin, Arnaud Tiberghien et al. · Clinical Cancer Research · 2018 · 86 citations

Medicine, Oncology, Pharmacology +17