Stephen J. Gregson

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon et al. · Bioconjugate Chemistry · 2013 · 241 citations

Drug Target, Immunology, Molecular Biology +21

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

John A. Hartley, Victoria J. Spanswick, Natalie Brooks et al. · Cancer Research · 2004 · 137 citations

Linker Length Modulates DNA Cross-Linking Reactivity and Cytotoxic Potency of C8/C8‘ Ether-Linked C2-<i>exo</i>-Unsaturated Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine (PBD) Dimers

Stephen J. Gregson, Philip W. Howard, Darren R. Gullick et al. · Journal of Medicinal Chemistry · 2004 · 92 citations

SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

Michael C. Alley, Melinda G. Hollingshead, Christine Pacula-Cox et al. · Cancer Research · 2004 · 83 citations

Hollow Fiber Assays, Molecular Biology, Nsc 694501 +21