David E. Thurston

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon et al. · Bioconjugate Chemistry · 2013 · 246 citations

Pharmacy, Oncology, Pharmacology +17

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Ricarda M. Hoffmann, Ben G T Coumbe, Debra H. Josephs et al. · OncoImmunology · 2017 · 179 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

Laurence H. Hurley, Teri Reck, David E. Thurston et al. · Chemical Research in Toxicology · 1988 · 140 citations

Medicine, Medicinal Chemistry, Pharmacology +9

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

John A. Hartley, Victoria J. Spanswick, Natalie Brooks et al. · Cancer Research · 2004 · 137 citations

Medicine, Oncology, Pharmacology +15