Concepedia

Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients

J. Greg Slatter, Larry J. Schaaf, James P. Sams, Kenneth L. Feenstra, Mark G. Johnson, Paul A. Bombardt, K. S. Cathcart, Michael T. Verburg, Laura Pearson, Linda D. Compton,

Drug Metabolism and Disposition · 2000 · 299 citations · 36 references

DOI

Concepts

References

36

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

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Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

, , +13

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

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Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

Takehiko Kunimoto, Kazuo Nitta, Takashi Tanaka et al. · PubMed · 1987 · 412 citations

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The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

Thomas G. Burke, Zihou Mi · Journal of Medicinal Chemistry · 1994 · 326 citations

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