Photoactivatable CRISPR-Cas9 for optogenetic genome editing

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.4K citations

Single Crispr Array, Engineering, Short Rnas +12

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.2K citations · Full text

Engineering, Genetics, Molecular Biology +16

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Lei S. Qi, Matthew H. Larson, Luke A. Gilbert et al. · Cell · 2013 · 5K citations · Full text

Off-target Effect, Engineering, Rna-guided Platform +9

DNA targeting specificity of RNA-guided Cas9 nucleases

Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.8K citations · Full text

Molecular Biology, Gene Editing, Genome Editing +3

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell · 2013 · 3.3K citations · Full text

Rna-guided Crispr Cas9, Genetics, Molecular Biology +7