Concepedia
Drug Metabolism and Disposition · 2003 · 183 citations · 35 references
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Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
J. Brian Houston, Kathryn E. Kenworthy · Drug Metabolism and Disposition · 2000 · 392 citations
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.
Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations
Pharmaceutical Science, Pharmaceutical Chemistry, Aldehyde Dehydrogenase +15
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
Victoria A. Eagling, John Tjia, David Back · British Journal of Clinical Pharmacology · 1998 · 334 citations · Full text