IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION

Denis Projean, Bruno Baune, Robert Farinotti, +4

Drug Metabolism and Disposition

New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ Opioid Receptor Agonists with Increased In Vitro Metabolic Stability

Niklas Plobeck, Daniel Delorme, Zhongyong Wei, +19

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryDelta BindingAbuse Liability Profile +13

Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N -demethylation in human liver microsomes

Denis Projean, Pierre-Emmanuel Morin, Tao Tu, +1

Xenobiotica

Major Cytochrome P450Molecular BiologyPharmacotherapySystem PharmacologyExperimental Pharmacology +16

Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats

Eric Grazzini, Carole Puma, Marie‐Odile Roy, +10

Proceedings of the National Academy of Sciences

<i>N,N</i>-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide:  A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues

Zhongyong Wei, W. A. Brown, Bryan K. Takasaki, +21

Journal of Medicinal Chemistry

Oral BioavailabilityPharmacotherapyExperimental PharmacologyPharmaceutical ChemistryPharmacodynamic Modeling +16

Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity

Julie Ducharme, Sami Abdullah, Irving W. Wainer

Journal of Chromatography B Biomedical Sciences and Applications

Pharmaceutical ScienceBiochemistryCyp3a ActivityMedicineDrug Discovery +6

Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium

France Varin, Julie Ducharme, Yves Théorêt, +3

Clinical Pharmacology & Therapeutics

Effect of mdr1a P-Glycoprotein Gene Disruption, Gender, and Substrate Concentration on Brain Uptake of Selected Compounds

Claude Dagenais, Jian Zong, Julie Ducharme, +1

Pharmaceutical Research

Uptake and efflux of the peptidic delta-opioid receptor agonist [D-penicillamine2,5]-enkephalin at the murine blood–brain barrier by in situ perfusion

Claude Dagenais, Julie Ducharme, Gary M. Pollack

Neuroscience Letters

Molecular PharmacologyMurine Blood–brain BarrierNeurophysiologyMedicineNeuropharmacology +8

Importance of Early Blood Sampling on Vecuronium Pharmacokinetic and Pharmacodynamic Parameters

Julie Ducharme, France Varin, David R. Bevan, +1

Clinical Pharmacokinetics

Pharmacokinetic ModelingVecuronium PharmacokineticMedicineHematologyPharmacology +6