Concepedia

Author

Denis Projean

AstraZeneca (Canada)

Also Known As

D. Projean, Denis Projean, Kristine Goyette, Projean, Denis

19

Publications

814

Citations

10

H-Index

30

Concepts

All Affiliations

AstraZeneca (Canada)Université de MontréalAstraZeneca (Sweden)AstraZeneca (United Kingdom)
DP

About

Denis Projean is an author at AstraZeneca (Canada) specializing in medicine, pharmacology, and molecular pharmacology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

6

6

386

2

Biochemistry

4

4

324

3

Health Sciences

3

3

93

4

Natural Sciences

3

3

293

5

Molecular Biology

1

1

97

Denis Projean

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9

Publications

702

Citations

9

H-Index

YearCitations

IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION

Denis Projean, Bruno Baune, Robert Farinotti,

Drug Metabolism and Disposition

2003

183

New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ Opioid Receptor Agonists with Increased In Vitro Metabolic Stability

Niklas Plobeck, Daniel Delorme, Zhongyong Wei,

Journal of Medicinal Chemistry

2000

115

Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N -demethylation in human liver microsomes

Denis Projean, Pierre-Emmanuel Morin, Tao Tu,

Xenobiotica

2003

97

Practical use of the regression offset approach for the prediction of<i>in vivo</i>intrinsic clearance from hepatocytes

Anna-Karin Sohlenius-Sternbeck, Chris Jones, Douglas Ferguson,

Xenobiotica

2012

92

<i>N,N</i>-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide:  A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues

Zhongyong Wei, W. A. Brown, Bryan K. Takasaki,

Journal of Medicinal Chemistry

2000

81

Cytochrome P450 Inhibitory Properties of Common Efflux Transporter Inhibitors

Gunilla Englund, Patrik Lundquist, Cristine Skogastierna,

Drug Metabolism and Disposition

2014

41

Rapid and simple method to determine morphine and its metabolites in rat plasma by liquid chromatography–mass spectrometry

Denis Projean, The Minh Tu, Julie Ducharme

Journal of Chromatography B

2003

32

Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model of Inflammatory Pain

Denis Projean, Sophie Dautrey, Huy Khan Vu,

Pharmaceutical Research

2005

31

Discovery of P2X3 selective antagonists for the treatment of chronic pain

Louis‐David Cantin, Malken Bayrakdarian, Christophe Buon,

Bioorganic & Medicinal Chemistry Letters

2012

30

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