β Galactosidase Enzyme Fragment Complementation as a High-Throughput Screening Protease Technology

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides

E. T. Kaiser, Robert L. Colescott, C.D. Bossinger et al. · Analytical Biochemistry · 1970 · 3.5K citations

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

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Pharmacy, Medicinal Chemistry, Pharmacology +16

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

Victor Ona, Mingwei Li, Jean Paul Vonsattel et al. · Nature · 1999 · 644 citations

Life Sciences, Molecular Biology, Neurology +11

Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal Cells

Cheryl L. Wellington, Roshni R. Singaraja, Lisa Ellerby et al. · Journal of Biological Chemistry · 2000 · 363 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17