Concepedia

Proteolytic Enzyme Activity

Proteolytic Enzyme Activity is a biochemical process characterized by the catalytic breakdown of peptide bonds in proteins, mediated by enzymes known as proteases, which selectively hydrolyze specific target proteins within the extracellular matrix or cellular compartments during connective tissue degradation.

11.1K

Publications

628.3K

Citations

36.8K

Authors

5.1K

Institutions

Publications per year

2017–2026

924

Parents

Publications

11.1K

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

, , +17

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

M. Gross-Bellard, P Oudet, Pierre Chambon · European Journal of Biochemistry · 1973 · 1.7K citations · Full text

, , +14

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

, , +14

Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

Chad Vickers, Paul Hales, Virendar K. Kaushik et al. · Journal of Biological Chemistry · 2002 · 1.4K citations · Full text

, , +17

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

1–5 of 11.1K

Authors

36.8K

  1. AL
    Alfred L. Goldberg

    Harvard University, United States

    46 publications · 6.2K citations

    38

    h-index

  2. AJ
    A. John Barrett

    National Heart Lung and Blood Institute, United States

    33 publications · 5K citations

    28

    h-index

  3. CO
    Claus Oxvig

    Aarhus University, Denmark

    29 publications · 2.9K citations

    26

    h-index

  4. CS
    Charles S. Craik

    University of California, San Francisco, United States

    27 publications · 2.4K citations

    23

    h-index

  5. JT
    James Travis

    University of Georgia, United States

    28 publications · 3K citations

    23

    h-index

1–5 of 36.8K

Institutions

5.1K

  1. Harvard University

    Cambridge, United States

    71 h-index

    466 publications

    68K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    57 h-index

    602 publications

    40.4K citations

  3. Inserm

    Paris, France

    56 h-index

    545 publications

    35.7K citations

  4. National Institutes of Health

    Bethesda, United States

    49 h-index

    250 publications

    17.8K citations

  5. University of California, San Francisco

    San Francisco, United States

    49 h-index

    313 publications

    33.5K citations

  6. University of Washington

    Seattle, United States

    43 h-index

    197 publications

    17K citations

  7. Stanford University

    Stanford, United States

    41 h-index

    175 publications

    15.2K citations

  8. The University of Tokyo

    Tokyo, Japan

    41 h-index

    420 publications

    25K citations

1–8 of 5.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 1K publications · 101.3K citations

    160

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 193 publications · 30.3K citations

    94

    h-index

  3. PubMed

    Repository · 473 publications · 20.3K citations

    67

    h-index

  4. Biochemical Journal

    BJ · 266 publications · 15.2K citations

    62

    h-index

  5. European Journal of Biochemistry

    EJB · 243 publications · 14.5K citations

    62

    h-index

1–5