Concepedia

Connective Tissue Breakdown

Connective Tissue Breakdown is a pathological catabolic process in periodontal tissues characterized by the enzymatic and inflammatory-mediated degradation of collagen fibers and other extracellular matrix components of the gingival and periodontal ligament connective tissue, leading to loss of attachment and structural integrity.

2.3K

Publications

134.4K

Citations

7.1K

Authors

1.7K

Institutions

Publications per year

2017–2026

175

Parents

Children

Publications

2.3K

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

Lance A. Liotta, Karl Tryggvason, Spiridione Garbisa et al. · Nature · 1980 · 1.8K citations

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Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture

Lawrence C. Hurst, Marie A. Badalamente, Vincent R. Hentz et al. · New England Journal of Medicine · 2009 · 700 citations · Full text

, , +9

Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis

Linda Chung, Deendayal Dinakarpandian, N. Yoshida et al. · The EMBO Journal · 2004 · 673 citations · Full text

, , +14

Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques

Galina K. Sukhova, Uwe Schönbeck, Elena Rabkin et al. · Circulation · 1999 · 649 citations

, , +12

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

Patrick Garnero, Olivier Borel, I. Byrjalsen et al. · Journal of Biological Chemistry · 1998 · 641 citations · Full text

, , +16

1–5 of 2.3K

Authors

7.1K

  1. JS
    Jaro Sodek

    University of Toronto, Canada

    29 publications · 2.4K citations

    26

    h-index

  2. LM
    Lorne M. Golub

    Stony Brook University, United States

    20 publications · 1.9K citations

    19

    h-index

  3. AJ
    Allen J. Bailey

    University of Bristol, United Kingdom

    18 publications · 1.9K citations

    17

    h-index

  4. ME
    Marcel E. Nimni

    University of Southern California, United States

    16 publications · 1.8K citations

    15

    h-index

  5. LJ
    L. Jack Windsor

    Indiana University – Purdue University Indianapolis, United States

    14 publications · 653 citations

    14

    h-index

1–5 of 7.1K

Institutions

1.7K

  1. Harvard University

    Cambridge, United States

    32 h-index

    93 publications

    10.5K citations

  2. University of Toronto

    Toronto, Canada

    31 h-index

    149 publications

    8.7K citations

  3. National Institutes of Health

    Bethesda, United States

    27 h-index

    111 publications

    15.8K citations

  4. University of Manchester

    Manchester, United Kingdom

    22 h-index

    65 publications

    5.5K citations

  5. University of British Columbia

    Vancouver, Canada

    22 h-index

    68 publications

    7.8K citations

  6. University of Washington

    Seattle, United States

    21 h-index

    69 publications

    7.7K citations

  7. University of Helsinki

    Helsinki, Finland

    21 h-index

    98 publications

    6.3K citations

  8. University of Southern California

    Los Angeles, United States

    20 h-index

    59 publications

    5.5K citations

1–8 of 1.7K

Venues

  1. Journal of Biological Chemistry

    JBC · 80 publications · 9.2K citations

    54

    h-index

  2. PubMed

    Repository · 169 publications · 6K citations

    42

    h-index

  3. Journal of Periodontal Research

    97 publications · 4.8K citations

    38

    h-index

  4. Journal of Periodontology

    58 publications · 3.2K citations

    35

    h-index

  5. Journal of Dental Research

    JDR · 56 publications · 2.6K citations

    31

    h-index

1–5