Metastatic potential correlates with enzymatic degradation of basement membrane collagen

Lance A. Liotta, Karl Tryggvason, Spiridione Garbisa, +3

Nature

Basement Membrane CollagenBiochemistryNatural SciencesTissue PhysiologyMatrix Biology +5

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

Lance A. Liotta, R H Goldfarb, Rodney A. Brundage, +3

PubMed

PathologyCollagen Type VCollagen Type IvBasement MembraneCellular Physiology +18

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

Roberta Mazzieri, Laura Masiero, Lucia Zanetta, +4

The EMBO Journal

Signal TransductionRegulatory MechanismUrokinase-plasmin SystemCell-bound ReactantsCell-matrix Interaction +7

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

Tea Kalebic, Spiridione Garbisa, Bert M. Glaser, +1

Science

Basement Membrane CollagenBasement Membrane CollagensAngiogenesisEndothelial CellsOphthalmology +10

Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis

Massimo Donà, Isabella Dell’Aica, Fiorella Calabrese, +4

The Journal of Immunology

Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate

Spiridione Garbisa, Luigi Sartor, Susan Biggin, +3

Cancer

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

Anna T. Levy, Vittoria Cioce, Mark E. Sobel, +4

PubMed

PathologyTotal RnaCancer BiologyTumor BiologyCancer Cell Biology +14

Partial purification and characterization of a neutral protease which cleaves type IV collagen

Lance A. Liotta, Karl Tryggvason, Spiridione Garbisa, +2

Biochemistry

GlycobiologyMolecular BiologyPathologyEnzymatic ModificationNeutral Protease +14

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

Spiridione Garbisa, Rudy Pozzatti, Ruth J. Muschel, +5

PubMed

PathologyCell ProliferationCancer BiologyCellular PhysiologyTumor Biology +15

Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen.

Gianni Sava, Sonia Zorzet, Francesca Vita, +8

PubMed

Lung MetastasesPathologySelective TargetingCancer BiologyTumor Biology +15