Concepedia

Synthesis and antitumor activity of novel cyclopropapyrroloindole(CPI) derivatives bearing methoxycarbonyl and trifluoromethyl groups

Yasumichi Fukuda, Hirosuke Furuta, Futoshi Shiga, Yasuo Oomori, Yoshie Kusama, Hiroyuki Ebisu, Shiro Terashima

Bioorganic & Medicinal Chemistry Letters · 1997 · 32 citations · 22 references

DOI

Concepts

References

22

Duocarmycin A, a new antitumor antibiotic from Streptomyces.

ISAMI TAKAHASHI, Keiichi Takahashi, Michio Ichimura et al. · The Journal of Antibiotics · 1988 · 195 citations · Full text

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Preliminary toxicity studies with the DNA-binding antibiotic, CC-1065.

J. Patrick McGovren, George L. Clarke, Evelyn A. Pratt et al. · The Journal of Antibiotics · 1984 · 145 citations · Full text

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Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

, , +7

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

Martha A. Warpehoski, Ilse Gebhard, Robert C. Kelly et al. · Journal of Medicinal Chemistry · 1988 · 129 citations

, , +17

(+)- and ent-(-)-Duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA Alkylation Properties.Alkylation Site Models That Accommodate the Offset AT-Rich Adenine N3 Alkylation Selectivity of the Enantiomeric Agents

Dale L. Boger, Douglas S. Johnson, Weiya Yun · Journal of the American Chemical Society · 1994 · 118 citations

, , +7