Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

Masao Saitoh · The EMBO Journal · 1998 · 2.4K citations · Full text

Reductive Stress, Mitophagy, Direct Inhibitor +11

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Hidenori Ichijo, Eisuke Nishida, Kenji Irie et al. · Science · 1997 · 2.3K citations

Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

Willscott E. Naugler, Toshiharu Sakurai, Sunhwa Kim et al. · Science · 2007 · 1.9K citations

Den Administration, Immunology, Pathology +21

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume et al. · Genes & Development · 2002 · 1.3K citations · Full text

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Kei Tobiume, Atsushi Matsuzawa, Takumi Takahashi et al. · EMBO Reports · 2001 · 1.2K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +11