ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Atsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi, +7

Nature Immunology

InflammationToll-like ReceptorsTlr4-mediated Innate ImmunitySignal TransductionAutoimmune Disease +11

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

Takuya Noguchi, Hiroyasu Inoue, Takashi Tanaka

Journal of Biological Chemistry

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

Hideki Nishitoh, Hisae Kadowaki, Atsushi Nagai, +7

Genes & Development

The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

Takuya Noguchi, Kazuya Yamada, H. Inoue, +2

Journal of Biological Chemistry

GeneticsMolecular BiologyGenomicsProtein SynthesisBiosynthesis +19

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, +7

The EMBO Journal

Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1

Go Fujino, Takuya Noguchi, Atsushi Matsuzawa, +4

Molecular and Cellular Biology

Ask1 SignalosomeApoptosisImmunologyCell DeathReactive Oxygen Species +17

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

Hayato Nakagawa, Shin Maeda, Yohko Hikiba, +9

Gastroenterology

HepatologyMedicineLiver PhysiologyApoptosisHepatitis +9

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death

Takuya Noguchi, Kohsuke Takeda, Atsushi Matsuzawa, +5

Journal of Biological Chemistry

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

Takuya Noguchi, Ken J. Ishii, Hisashi Fukutomi, +4

Journal of Biological Chemistry

MitophagyLipid PeroxidationApoptosisImmunologyP38 Activation +18

Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties.

Masaaki Kobayashi, Ken Takamatsu, Shigeharu Saitoh, +1

Journal of Biological Chemistry

Native HippocalcinCytoskeletonMechanotransductionCellular PhysiologyHippocalcin Bound +14