Kaoru Saegusa

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume et al. · Genes & Development · 2002 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Atsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi et al. · Nature Immunology · 2005 · 659 citations

Life Sciences, Immunology, Molecular Biology +15

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death

Takuya Noguchi, Kohsuke Takeda, Atsushi Matsuzawa et al. · Journal of Biological Chemistry · 2005 · 217 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi et al. · Journal of Clinical Investigation · 2002 · 147 citations · Full text

Life Sciences, Immunology, Pathology +17

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Takayuki Iriyama, Kohsuke Takeda, Hiromi Nakamura et al. · The EMBO Journal · 2009 · 129 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +10