Synthesis of 4-arylaminoquinazolines via 2-amino-N-arylbenzamidines

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

David W. Fry, Alan J. Kraker, Amy McMichael et al. · Science · 1994 · 802 citations

Life Sciences, Oncology, Pharmacology +15

4-(Phenylamino)pyrrolopyrimidines:  Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Peter Traxler, Pascal Furet, Helmut Mett et al. · Journal of Medicinal Chemistry · 1996 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

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Pharmacy, Medicinal Chemistry, Pharmacology +15

Reaction of Anthranilonitrile and N-Methylanthranilonitrile with Phenyl Isocyanate and Phenyl Isothiocyanate¹

Edward C. Taylor, R. V. Ravindranathan · The Journal of Organic Chemistry · 1962 · 61 citations

Natural Sciences, Chemistry, Mass Spectrometric Analysis +4

STRUCTURE‐ACTIVITY RELATIONSHIPS FOR 4‐ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING SITE OF THE EPIDERMAL GROWTH FACTOR RECEPTOR <i>IN VITRO</i>

William A. Denny, Gordon W. Rewcastle, Alexander J. Bridges et al. · Clinical and Experimental Pharmacology and Physiology · 1996 · 33 citations

Medicine, Medicinal Chemistry, Pharmacology +17