Helmut Mett

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

Elisabeth Buchdunger, J. Zimmermann, Helmut Mett et al. · PubMed · 1996 · 1.1K citations

Abl Protein-tyrosine Kinase, Cellular Pharmacology, Pharmacotherapy +21

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J M Wood, Guido Bold, Elisabeth Buchdunger et al. · PubMed · 2000 · 846 citations

Immunology, Oral Administration, Pharmacotherapy +20

Different Susceptibility of Protein Kinases to Staurosporine Inhibition

Flavio Meggio, Arianna Donella Deana, Maria Ruzzene et al. · European Journal of Biochemistry · 1995 · 289 citations · Full text

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

Elisabeth Buchdunger, J. Zimmermann, Helmut Mett et al. · Proceedings of the National Academy of Sciences · 1995 · 269 citations · Full text

Immunology, Cell Growth, Signaling Pathway +17

Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

J. Zimmermann, Elisabeth Buchdunger, Helmut Mett et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 242 citations

Molecular Pharmacology, Medicinal Chemistry, Derivatives +13