J M Wood

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J M Wood, Guido Bold, Elisabeth Buchdunger et al. · PubMed · 2000 · 846 citations

Immunology, Oral Administration, Pharmacotherapy +20

VEGF is major stimulator in model of choroidal neovascularization.

Nohoon Kwak, N. Okamoto, J M Wood et al. · PubMed · 2000 · 447 citations

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum et al. · Chemistry & Biology · 2000 · 320 citations · Full text

Drug Target, Biochemistry, Drug Design +11

Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model.

Joachim Drevs, Ilse Hofmann, Harald Hugenschmidt et al. · PubMed · 2000 · 309 citations

Urology, Angiogenesis, Oncology +15

PKC412--a protein kinase inhibitor with a broad therapeutic potential.

D Fabbro, Stephan Ruetz, Stephan Bodis et al. · PubMed · 2000 · 270 citations

Chemoprevention Strategy, Metronomic Chemotherapy, Tumor Biology +17