Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid

Jeanette M. Wood, Karine Bonjean, Stephan Ruetz, +5

Journal of Pharmacology and Experimental Therapeutics

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

Stephan Ruetz

Cell

Molecular PhysiologyMdr2 GeneBiochemistryNatural SciencesMolecular Biology +2

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

Carlos Garcı́a-Echeverrı́a, Mark Pearson, Andreas Marti, +15

Cancer Cell

Cancer ResearchMedicineReceptor Tyrosine KinaseVivo Antitumor ActivityNvp-aew541—a Novel +7

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

Iwan Beuvink, Anne Boulay, Stefano Fumagalli, +7

Cell

P21 TranslationTumor BiologyApoptosisCell DeathDna-damaged Induced Apoptosis +6

PKC412--a protein kinase inhibitor with a broad therapeutic potential.

D Fabbro, Stephan Ruetz, Stephan Bodis, +7

PubMed

Chemoprevention StrategyMetronomic ChemotherapyTumor BiologyProtein Kinase InhibitorMolecular Pharmacology +15

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Philipp Holzer, Keiichi Masuya, Pascal Furet, +13

Journal of Medicinal Chemistry

Dihydroisoquinolinone DerivativeDrug TargetMolecular BiologyPharmacotherapyTumor Biology +16

Functional expression of P-glycoproteins in secretory vesicles.

Stephan Ruetz, Piet Gros

Journal of Biological Chemistry

Protein SecretionGlycobiologyMolecular BiologyCellular PhysiologyMembrane Transport +17

Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein

Hugh R. Goodfellow, Alessandro Sardini, Stephan Ruetz, +3

Journal of Biological Chemistry

Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805

Fabienne Baffert, Catherine H. Régnier, Alain De Pover, +19

Molecular Cancer Therapeutics

PharmacotherapyExcellent SelectivityPharmaceutical ChemistryMyeloid NeoplasiaHematological Malignancy +18

Isolation and characterization of the putative canalicular bile salt transport system of rat liver.

Stephan Ruetz, Gert Fricker, G. Hugentobler, +3

Journal of Biological Chemistry

Canalicular VesiclesGlycobiologyGastroenterologyDigestive TractCholangiopathies +20