Mark Pearson

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Mark Pearson, Roberta Carbone, Carla Sebastiani et al. · Nature · 2000 · 826 citations

P53 Acetylation, Oncogenic Ras, Cell Regulation +9

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Constantine S. Mitsiades, Nicholas Mitsiades, Ciaran J. McMullan et al. · Cancer Cell · 2004 · 610 citations

Hematological Malignancy, Solid Tumors, Medicine +9

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Manfred Koegl, Michael J. Roy et al. · Nature Chemical Biology · 2019 · 553 citations · Full text

Tumor Biology, Medicine, Natural Sciences +10

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

Carlos Garcı́a-Echeverrı́a, Mark Pearson, Andreas Marti et al. · Cancer Cell · 2004 · 535 citations · Full text

Cancer Research, Medicine, Receptor Tyrosine Kinase +9

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

Philipp Rathert, Mareike Roth, Tobias Neumann et al. · Nature · 2015 · 517 citations · Full text

Transcriptional Regulation, Lineage Plasticity, Developmental Biology +8