Concepedia

Synthesis and properties of a novel bridged nucleic acid with a P3′ → N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA

Satoshi Obika, Osamu Nakagawa, Akiko Hiroto, Yoshiyuki Hari, Takeshi Imanishi

Chemical Communications · 2003 · 26 citations · 21 references

DOI

Concepts

Abstract

5'-Amino-2',4'-BNA, a novel analogue of BNA series compounds, was successfully synthesized, and its incorporated oligonucleotides showed potent duplex- and triplex-forming ability and resistance against snake venom phosphodiesterase.

References

21

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

, , +16

Sequence‐Specific Recognition and Modification of Double‐Helical DNA by Oligonucleotides

Nguyen T. Thuong, Claude Hélène · Angewandte Chemie International Edition in English · 1993 · 624 citations

, , +15

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1997 · 601 citations

, , +13

The synthesis of modified oligonucleotides by the phosphoramidite approach and their applications

Serge L. Beaucage, Radhakrishnan P. Iyer · Tetrahedron · 1993 · 318 citations

, , +12

Oligonucleotide N3'-->P5' phosphoramidates.

Sergei Gryaznov, D. H. Lloyd, Jia-Kuan Chen et al. · Proceedings of the National Academy of Sciences · 1995 · 153 citations · Full text

, , +17