Concepedia

Phosphoramidate Oligonucleotides

Phosphoramidate Oligonucleotides is a class of modified oligonucleotides in which one of the non-bridging oxygen atoms in the phosphate backbone is replaced by a nitrogen-containing group, thereby conferring enhanced nuclease resistance and altered hybridization properties compared to natural phosphodiester oligonucleotides.

629

Publications

32.7K

Citations

1.8K

Authors

459

Institutions

Publications per year

2017–2026

42

Parents

Publications

629

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

Serge L. Beaucage, Marvin H. Caruthers · Tetrahedron Letters · 1981 · 2K citations

, , +7

Polymer support oligonucleotide synthesis XVIII<sup>1.2)</sup>: use of<i>β</i>-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

N. D. SINHA, J. Biernat, J. F. A. McManus et al. · Nucleic Acids Research · 1984 · 848 citations · Full text

, , +16

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

Serge L. Beaucage, Radhakrishman P. Iyer · Tetrahedron · 1992 · 708 citations

, , +11

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

Kay L. Nakamaye, Fritz Eckstein · Nucleic Acids Research · 1986 · 553 citations · Full text

, , +15

An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

Lincoln J. McBride, Marvin H. Caruthers · Tetrahedron Letters · 1983 · 513 citations

, , +10

1–5 of 629

Authors

1.8K

  1. SG
    Sergei Gryaznov

    Geron (United States), United States

    26 publications · 1.6K citations

    18

    h-index

  2. FS
    Frank Seela

    Osnabrück University, Germany

    22 publications · 692 citations

    17

    h-index

  3. SL
    Serge L. Beaucage

    Center for Drug Evaluation and Research, United States

    20 publications · 3.9K citations

    16

    h-index

  4. MH
    Marvin H. Caruthers

    University of Colorado Boulder, United States

    17 publications · 3.5K citations

    15

    h-index

  5. DL
    Douglas L. Cole

    Ionis Pharmaceuticals (United States), United States

    21 publications · 586 citations

    15

    h-index

1–5 of 1.8K

Institutions

459

  1. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    28 h-index

    223 publications

    16.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    93 publications

    4.5K citations

  3. Osnabrück University

    Osnabrück, Germany

    17 h-index

    55 publications

    1.6K citations

  4. University of Colorado Boulder

    Boulder, United States

    12 h-index

    50 publications

    7.2K citations

  5. Geron (United States)

    Menlo Park, United States

    12 h-index

    56 publications

    3.7K citations

  6. Berman Center for Outcomes and Clinical Research

    Minneapolis, United States

    11 h-index

    37 publications

    1.4K citations

  7. Université de Montpellier

    Montpellier, France

    11 h-index

    60 publications

    3.3K citations

  8. University of Konstanz

    Konstanz, Germany

    11 h-index

    30 publications

    438 citations

1–8 of 459

Venues

  1. Nucleic Acids Research

    86 publications · 6.7K citations

    46

    h-index

  2. Tetrahedron Letters

    52 publications · 4.5K citations

    26

    h-index

  3. The Journal of Organic Chemistry

    JOC · 30 publications · 1K citations

    21

    h-index

  4. Journal of the American Chemical Society

    JACS · 20 publications · 1.3K citations

    20

    h-index

  5. Tetrahedron

    19 publications · 1.7K citations

    16

    h-index

1–5