Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.1K citations

Molecular Biology, Tumor Biology, Signaling Pathway +16

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta et al. · Molecular Cell · 2006 · 2.6K citations · Full text

Molecular Pharmacology, Medicine, Receptor Tyrosine Kinase +4

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt et al. · Nature Cell Biology · 2004 · 2.1K citations

Signal Transduction, Natural Sciences, Cell Interaction +10

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila et al. · PLoS Biology · 2009 · 1.1K citations · Full text

Drug Target, Mrna Translation, Molecular Biology +24