Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali, +1

Science

Molecular BiologyTumor BiologySignaling PathwayAkt/pkb ActivationReceptor Tyrosine Kinase +14

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta, +5

Molecular Cell

Molecular PharmacologyMedicineReceptor Tyrosine KinasePharmacotherapyPharmacology +2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt, +4

Nature Cell Biology

Signal TransductionNatural SciencesCell InteractionActin CytoskeletonMolecular Biology +8

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang, +7

Journal of Biological Chemistry

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila, +4

PLoS Biology

Drug TargetMrna TranslationMolecular BiologyPharmacotherapyChemical Biology +22

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

David A. Guertin, Deanna M. Stevens, Maki Saitoh, +7

Cancer Cell

Signal TransductionSignaling PathwayCell RegulationMedicineMtor Complex 2 +9

Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi, +15

Cancer Research

Chemoprevention StrategyCellular PharmacologySelective InhibitorsMtor SelectivityChemical Biology +20

mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

Janine Masri, Andrew Bernath, Jheralyn Martin, +4

Cancer Research

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

Piotr Rychahou, JungHee Kang, Pat Gulhati, +5

Proceedings of the National Academy of Sciences

Akt2 OverexpressionEpigenetic RegulationMedicineCritical RolePten Mutation +13

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in <i>Apc</i> ^Δ716 mice

Teruaki Fujishita, Koji Aoki, Heidi A. Lane, +2

Proceedings of the National Academy of Sciences

Gastrointestinal PharmacologyApoptosisImmune RegulationPathologyCell Death +19