Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

George J. Todaro, Howard Green · The Journal of Cell Biology · 1963 · 2.8K citations · Full text

Life Sciences, Biology, Cell Biology +12

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

Masashi Narita, Sabrina Nuñez, Édith Heard et al. · Cell · 2003 · 2.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

Medicine, Molecular Biology, Oncology +16

Effects of an Rb mutation in the mouse

Tyler Jacks, Amin Fazeli, Earlene M. Schmitt et al. · Nature · 1992 · 1.8K citations

Medicine, Genetics, Molecular Genetics +11