CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes

Haruna Takeda, Shiho Kataoka, Mizuho Nakayama, +9

Proceedings of the National Academy of Sciences

RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity

Teruyuki Muraguchi, Yujiro Takegami, Toshiyuki Ohtsuka, +9

Nature Neuroscience

Cortical NeurogenesisNeuroregenerationDevelopmental BiologyMolecular NeuroscienceSignaling Pathway +9

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

Awad Shamma, Yujiro Takegami, Takao Miki, +5

Cancer Cell

ChromatinGenome InstabilityDna DamageCell RegulationE2f-dependent Suppression +6

NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki, +13

Nature Genetics

Transcriptional RegulationFunctional GenomicsNatural SciencesGeneticsMolecular Biology +10

The Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) Interacts with Membrane Type 1 Matrix Metalloproteinase and CD13/Aminopeptidase N and Modulates Their Endocytic Pathways

Takao Miki, Yujiro Takegami, Katsuya Okawa, +3

Journal of Biological Chemistry

PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation

Kenji Shimizu, Daisuke Sugiura, Il‐mi Okazaki, +5

Molecular Cell

T Cell ActivationSignal TransductionCell RegulationMedicineT-regulatory Cell +10

DUX4 is a multifunctional factor priming human embryonic genome activation

Sanna Vuoristo, Shruti Bhagat, Christel Hydén‐Granskog, +30

iScience

Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor

Chiaki Takahashi, Bernardo Contreras, Tsuyoshi Iwanaga, +7

Nature Genetics

Thyroid DiseasePathologyThyroid HormoneMedicineCell Biology +2

Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling

Shunsuke Kitajima, Takao Miki, Yujiro Takegami, +5

Oncogene

Signal TransductionSignaling PathwayReceptor Tyrosine KinaseKazal MotifsReversion-inducing Cysteine-rich Protein +5

The β1-Integrin–Dependent Function of RECK in Physiologic and Tumor Angiogenesis

Takao Miki, Awad Shamma, Shunsuke Kitajima, +5

Molecular Cancer Research

ImmunologyCellular PhysiologyTumor BiologyVascular Endothelial CellsTumor Angiogenesis +20