Concepedia

Detection of Ligands from a Dynamic Combinatorial Library by X‐ray Crystallography

Miles Congreve, Deborah Davis, Lindsay A. Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Angewandte Chemie International Edition · 2003 · 97 citations · 17 references

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Abstract

A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.

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