Concepedia

Utilization of Fluorescence Polarization and Time Resolved Fluorescence Resonance Energy Transfer Assay Formats for SAR Studies: Src Kinase as a Model System

Miki Newman, Serene Josiah

SLAS DISCOVERY · 2004 · 22 citations · 16 references

DOIFull text

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Concepts

References

16

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

, , +16

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry · 1996 · 2K citations · Full text

, , +17

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

Jamey D. Marth, Richard Peet, Edwin G. Krebs et al. · Cell · 1985 · 542 citations · Full text

, , +14

Activation of Src kinase in primary colorectal carcinoma

Heike Allgayer, Douglas D. Boyd, M. M. Heiss et al. · Cancer · 2002 · 250 citations · Full text

, , +17