Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

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Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

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An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

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Terfenadine-Ketoconazole Interaction

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The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

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