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Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines

Christopher S. Burgey, Craig M. Potteiger, James Z. Deng, Scott D. Mosser, Christopher Salvatore, Sean Yu, Shane Roller, Stefanie A. Kane, Joseph P. Vacca, Theresa M. Williams

Bioorganic & Medicinal Chemistry Letters · 2009 · 20 citations · 14 references

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14

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Jes Olesen, Hans‐Christoph Diener, Ingo W. Husstedt et al. · New England Journal of Medicine · 2004 · 1.2K citations · Full text

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A Versatile Catalyst for Heck Reactions of Aryl Chlorides and Aryl Bromides under Mild Conditions

Adam F. Littke, Gregory C. Fu · Journal of the American Chemical Society · 2001 · 690 citations

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Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

Tony W. Ho, Michel D. Ferrari, David W. Dodick et al. · The Lancet · 2008 · 529 citations

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Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

Tony W. Ho, L. K. Mannix, Xiaoyin Fan et al. · Neurology · 2007 · 465 citations

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The CGRP-Antagonist, BIBN4096BS Does not Affect Cerebral or Systemic Haemodynamics in Healthy Volunteers

Steffen Birk, LH Lassen, Christina Kruuse et al. · Cephalalgia · 2005 · 181 citations

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