Shane Roller

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 370 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12

Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

Yulin Wu, Christopher Aquino, David J. Cowan et al. · Journal of Medicinal Chemistry · 2013 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

Ian M. Bell, Steven N. Gallicchio, Michael R. Wood et al. · ACS Medicinal Chemistry Letters · 2010 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and SAR of Benzisothiazole- and Indolizine-β-<scp>d</scp>-glucopyranoside Inhibitors of SGLT2

Huiqiang Zhou, Dana P. Danger, Steven T. Dock et al. · ACS Medicinal Chemistry Letters · 2010 · 51 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Role of Glutathione <i>S-</i>Transferases A1-1<i>, </i>M1-1, and P1-1 in the Detoxification of 2-Phenylpropenal, a Reactive Felbamate Metabolite

Christine M. Dieckhaus, Shane Roller, Webster L. Santos et al. · Chemical Research in Toxicology · 2001 · 34 citations

Medicine, Biochemistry, Pharmacology +15