Concepedia

Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy

Yu-Wen Li, Geraldine Hill, Harvey Wong, Natasha Kelly, Marie Pierdomenico, Shelly X. Ren, Paul J. Gilligan, Scott Grossman, George L. Trainor, Rebecca Taub,

Journal of Pharmacology and Experimental Therapeutics · 2003 · 60 citations · 28 references

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28

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Peter Timpl, Rainer Spanagel, Inge Sillaber et al. · Nature Genetics · 1998 · 934 citations

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Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

DT Chalmers, T. W. Lovenberg, EB De Souza · Journal of Neuroscience · 1995 · 922 citations · Full text

, , +16

Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

J. Douglas Bremner, Júlio Licinio, Adam Darnell et al. · American Journal of Psychiatry · 1997 · 717 citations

, , +13

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

Astrid Zobel, Thomas Nickel, Heike Künzel et al. · Journal of Psychiatric Research · 2000 · 704 citations

, , +14

Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

Kamal E. Habib, Katherine P Weld, Kenner C. Rice et al. · Proceedings of the National Academy of Sciences · 2000 · 402 citations

, , +17