Shelly X. Ren

Discovery of (<i>R</i>)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-<i>N</i>-(3-(7-methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

Andrew P. Degnan, Prasad V. Chaturvedula, Charles M. Conway et al. · Journal of Medicinal Chemistry · 2008 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy

Yu-Wen Li, Geraldine Hill, Harvey Wong et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 60 citations

Medicine, Neuroscience, Pharmacology +14

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats

Snježana Lelas, Harvey Wong, Yu-Wen Li et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 55 citations

Medicine, Pharmacology, Pharmacotherapy +15

N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

Kan He, Mingxin Qian, Harvey Wong et al. · Journal of Pharmaceutical Sciences · 2007 · 29 citations

Pharmacy, Pharmacokinetics, Pharmacology +8

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1

Xiaojun Han, Rita L. Civiello, Charles M. Conway et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 16 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12